INNOVATIVE BIORESEARCH

Innovative Bioresearch is a privately held biotech company based in Italy. Owned and founded by research scientist Jonathan Fior with the goal of bringing innovation to the field, with a focus on HIV, cancer and regeneration research. We are launching a Token Sale for supporting our AIDS (Acquired Immunodeficiency Sindrome associated with HIV infection) cure research, as well as to develop an application providing a on one hand a decentralized database for clinical data generated by our future human trials, to overcome the limitations of the current ancient centralized databases, and on the other hand a social platform for the HIV seropositive community and our future services.

THE CHALLENGE OF HAVING TO ACCESS CLINICAL DATA FROM THE CURRENT ANCIENT CENTRALIZED DATABASES

Traditionally, all data generated by scientific research is collected in the form of a scientific article, which is published in a peer reviewed scientific journal, and it is usually made available on a public database such as the NIH’s pubmed database (https://www.ncbi.nlm.nih.gov/pubmed). When a novel therapeutic strategy, such as SupT1 cell infusion therapy, goes through the several stages of clinical research, different research teams all over the world may perform the research. And once the therapy is finally approved for human treatment, different clinicians all over the world may administer the treatment to patients. This means that when a research team wants to perform clinical research, they have to go through the tedious and time consuming process of searching for all the published data from previous trials, read all the papers, select the useful data, and make the best possible interpretation of the data to create a protocol for their trial, personalizing it for their typology of patients.

In fact, every patient may have different individual characteristics (e.g., age, ethnicity, HIV tropism) and thus may require personalized treatment protocols. And the same issue is present when clinicians begin to administer an approved treatment to patients; they have to go through all the papers and make a best guess on what treatment protocol should be used. As mentioned, this process of accessing clinical data can be quite tedious and time consuming, but it can also introduce human error.

A Possible Solution: A Decentralized Database Using the Blockchain to Store and Access Clinical Data

A possible solution to the challenge posed by having to access clinical data from the current ancient system could be provided by the creation of a decentralized database for clinical data using the blockchain technology. This is what we are proposing with the creation of the “You’re not alone” application. First, let’s focus on the blockchain aspect of the app, we will explain why it has such a name later. The “You’re not alone” app would feature a user-friendly interface allowing any clinician running a clinical investigation to enter the data produced by their trials.

The application would allow the input of a broad range of individual parameters for each treated patient, such as age, ethnicity, disease progression stage, viral tropism of HIV virus carried, along with the clinical protocol used (e.g., dosage of SupT1 cells infused each week) and the outcome of the treatment (e.g., viral load, CD4+ T cell count). The app would then access and elaborate the data on the fly; statistical analysis (means, standard deviations, correlations, power) and even the elaboration of suggested treatment profiles that could work best for each type of patient could be performed. This would take away the burden of having to manually search and process all the data from current centralized databases, which often involves printing hundreds of papers. And such an application would have an infinite potential for growing. For instance, an amazing feature could be to store in the database the genotypic information of the HIV virus carried by each patient, allowing to keep track of all mutations and genetic modifications caused by the treatment as well as the resulting viral phenotypic changes. Therefore, such a database would be constantly growing and evolving as new parameters are added to it, and it would be always available, anytime, anywhere, and to anyone connected.

Another important aspect is that usually in a scientific publication the raw data is not published but instead a graphical representation is used to summarize the data; another amazing feature of a decentralized database is that due to not having the editorial constraints of a scientific journal, the whole raw data generated by any research could be included in the database. Such an app would help speed up tremendously the clinical development stages of our AIDS cure research; it could be a game changer. We would still publish the data through the traditional peer reviewed system, but once reviewed and published, the data would also be made immediately available for easy access through the application.

These are some of the potential advantages of using the blockchain technology for creating a decentralized database for clinical data

• Immutability. Scientific data need to be immutable. Once a study is peer reviewed and published, its data must be permanently stored and never altered. In the blockchain, all data is stored in every single node, never ceasing to exist, and always staying on the blockchain. It is immutability that gives the blockchain its openness and BFT (Byzantine Fault Tolerance).

• Decentralization. The blockchain is designed to be distributed and synchronized across networks, making data freely available to anyone. We believe that scientific data should be shared and not being hidden behind a firewall.

• Security. The kind of transactions that can be performed are strictly defined in advance and stored in the blockchain as “smart contracts”; this prevents fraudulent data from being added to the blockchain thus ensuring integrity of the database. By contrast, it would be much easier to compromise a centralized database.

Here are some of the potential drawbacks

• Transaction slowness. Bitcoin has a limit of 7 transactions per second, while Etherum has 15. This could be a limit for applications that may require thousands or even million database transactions per second. However, this would hardly be the case for a scientific database where data would be entered at a much slower pace, given that it can require several moths to years for a clinical study to be completed and new data to be produced.

• Data storage is primitive. The blockchain uses a rather primitive key-value database. However, although this could be a problem for applications storing complex databases, scientific data often consist of simple sets of alphanumeric data that could easily be stored in the blockchain by compressing and storing them in Hexadecimal format.

We are planning to use this application specifically for our AIDS cure research, to overcome the limitations of current centralized databases. However, we believe there may be interest in using our application by other parties. After all, this would be an application designed by a research scientist for research scientists. Our database will be open to any company or institution interested in using our app for storing their clinical data. Moreover, we will encourage them to do so as we believe that scientific data should shared publicly.

Now, let’s explain why we named the application “You’re not alone”. The application will also document the progress of our AIDS cure research project, featuring periodic updates such as articles, vlogs. This will create a community where HIV seropositive people can stay up to the date, comment, share, interact with us working on the cure, and with each others. Something that creates a bridge between HIV seropositive people and us, research scientists working on the cure. Something that allows the HIV seropositive community and anyone interested to be part of this journey. Something that can send the message that they are not alone in their battle. That we are fighting for them. That we care about them. A message of hope. Our vision and intention is therefore to create an application that will also act as a social app for HIV seropositive people to participate and create new topics and discussions to support each others and stand together in the fight against AIDS.

“YOU’RE NOT ALONE” SOCIAL FEATURES

The application will also provide our official channel through which patients will be able to access the therapy by providing information about all the ongoing clinical trials, how to participate, and once our HIV treatment is approved, it will provide information about the clinics and hospitals offering the treatment, and how to book appointments with legit clinicians that are officially collaborating with us, to offer the best services and rates.

INNBC TOKEN ECONOMY

INNBC Token and Sale details

• Hard Cap: 50million INNBC Tokens (including pre sale)

• Payment Methods: ETH

• Number of INNBC for Pre-Sale: 20,000,000

• Number of INNBC for Sale: 30,000,000

The INNBC Token will be an ERC20 token released on the Etherum blockchain, and there will be only one initial limited supply of INNBC Tokens. Innovative Bioresearch intends to also use funds received during Token sale for further development of the project, payment of salaries and future expenses.
This will help accelerate development and also enable the team to work full time with total commitment. Only Tokens sold are actually minted at the end of the Token sale, meaning that total supply will consist of sold Tokens plus Tokens reserved by Innovative Bioresearch. Innovative Bioresearch will reserve up to 100,000,000 Tokens for supporting Token economy and these Tokens will not be available for sale.

The INNBC token may be used once all purchased INNBC tokens will be distributed to purchasers. Also, holders of INNBC tokens are free to sell their tokens to users who need those for access to our platform.

INNBC Pricing

INNBC Token emission price is 1EUR (1,23USD) per 1INNBC, corresponding to 415INNBC per 1ETH, with respect to the ETH/EUR exchange rate on the day of smart contract creation (16 April 2018). Minimum purchase is 10 INNBC Tokens.

During Token sale, we will offer the following discounts

• 20% discount for pre-sale (498INNBC per 1ETH).

• 10% discount for the successive sale (456INNBC per 1ETH).

Fund Distribution

TIMELINE

TEAM

For more information, please visit:

Website : http://innovativebioresearch.com/

Whitepaper : https://goo.gl/yJhd87

Facebook : https://www.facebook.com/innovativebioresearch

Twitter : https://twitter.com/InnBioresearch

Telegram: https://t.me/innovativebioresearch

ANN Thread : https://bitcointalk.org/index.php?topic=3378302

YouTube: https://www.youtube.com/channel/UCbzc1KBQHAq4O7GzM-Jt6Lw

Author: Crator Touch

My Bitcointalk Profile: https://bitcointalk.org/index.php?action=profile;u=1612381

My Ethereum Address: 0x4883E31Bb22ec89Dd8ddbf24C7F57C1317C58F7d