Ayahuasca

Ayahuasca is an entheogenic brew made out of Banisteriopsis caapi vine and other ingredients. The brew is used as a traditional spiritual medicine in ceremonies among the indigenous peoples of the Amazon basin and is known by a number of different names .

B. caapi contains several alkaloids that act as monoamine oxidase inhibitors (MAOIs). Another common ingredient in ayahausca is the shrub Psychotria viridis which contains the primary psychoactive compound, dimethyltryptamine (DMT). MAOIs are required for DMT to be orally active.

Effects...

People who have consumed ayahuasca report having mystical or religious experiences and spiritual revelations regarding their purpose on earth, the true nature of the universe as well as deep insight into how to be the best person they possibly can. This is viewed by many as a spiritual awakening and what is often described as a rebirth. In addition, it is often reported that individuals feel they gain access to higher spiritual dimensions and make contact with various spiritual or extra-dimensional beings who can act as guides or healers.

Author Don Jose Campos claims that people may experience profound positive life changes subsequent to consuming ayahuasca. Vomiting can follow ayahuasca ingestion; this purging is considered by many shamans and experienced users of ayahuasca to be an essential part of the experience, as it represents the release of negative energy and emotions built up over the course of one's life. Others report purging in the form of vomiting, diarrhea, and hot/cold flushes.

The ingestion of ayahuasca can also cause significant, but temporary, emotional and psychological distress. Excessive use could possibly lead to serotonin syndrome (although serotonin syndrome has never been specifically caused by Ayahuasca, only if in conjunction with certain anti-depressants like SSRI's). The temporary non-entheogenic effects of Ayahuasca can, depending on dosage, include tremors, nausea, vomiting, diarrhea, autonomic instability, hyperthermia, sweating, motor function impairment, sedation, relaxation, vertigo, dizziness, and muscle spasms, which are primarily caused by the Harmala alkaloids in Ayahuasca. Long-term negative effects are not known.A few deaths due to participation in the consumption of ayahuasca have been reported, although none have been linked specifically to Ayahuasca itself, but are usually said to be due to other factors. Some of the deaths may have been due to unscreened preexisting heart conditions, interaction with drugs, such as antidepressants, recreational drugs, caffeine (due to the CYP1A2 inhibition of the Harmala alkaloids), or nicotine (from drinking Tobacco tea for purging/cleansing), or from improper or irresponsible use due to behavioral risks or possible drug to drug interactions.

In 2018, it was reported that a single dose of ayahuasca significantly reduced symptoms of treatment-resistant depression in a small placebo-controlled trial.

Source:wikipedia