Well there is a very positive side to knowing nothing really matters, that liberation of bullshit is very necessary for us to really see.
and when you know nothing matters the world will become your playground, you'll do whatever the fuck you want.
if you wanna rest then rest, if you wanna work then work.
The bottom line is this, that we all are going to waste in this vast universe that we don't have any understanding of, might as well do what feels right. :) <3