Nice writeup. As someone who's both fascinated by psychedelics and a bit of a pharmacogenetics/epigenetics nerd I have to wonder what changes on genetic expression may come from doing Kambo, and if that aspect could contribute to some of the lore around it, especially in the immune/detox deptartment. I mention it because there's some interesting research on proteomic/epigenetic changes from 5-MEO DMT relating to inflammatory immune markers (although this was an in-vitro study) which is a primary ingredient in our other favorite psychedelic frog, bufo alvarius.
https://www.nature.com/articles/s41598-017-12779-5
Of course, "well chalk it up to epigenetics" is an easy catch all these days, but without those studies I have to wonder, especially when there are traditional/folk claims made about the immune system.
And, granted, 5-MEO DMT is a totally different class of molecule, but I bring it up because I'd be also mad skeptical about claims about it's anti-inflammatory effects without seeing that nature study.
Ty for commenting.
Your theory sounds very interesting, and I guess epigenitic changes are theoretically possible. However, there's no research whatsoever on that topic yet (or at least I'm not aware of) , so all one can do is speculate.