I hope that this way of thinking becomes the "norm".
We talk about relativity, relationships and networks often enough.

So support or imbalance in one environment is going to be reflected elsewhere. Might appear as some likeness, or polarity.

This is observed everywhere.

Immune response can be detected early- absence of familiar sense of satisfaction, motivation, pleasure or focus. Might blame it on the coffee or drug of choice. Usually within 24 hours a more obvious sign of illness or irritation arrives. That has been my experience.

Where depression is chronic, it can be difficult to pick up on this. There is not much left to differentiate. Finding a reason to care can be a chore.