Ultimate Marvel

T'Challa, the younger son of King T'Chaka of Wakanda, is severely injured during the "Trial of the Panther" from which the protector of the nation is selected. His older brother M'Baku finds T'Challa bloodied, mute, and near death but derisively calls him a fool for attempting the trial. Later, M'Baku adds that he, not T'Challa, should have taken the trial. Angry that his father has decided to share Wakanda's technology in exchange for America's help in saving T'Challa's life, M'Baku leaves the kingdom.

To save T'Challa, T'Chaka turns him over to the Weapon X program. Over a year later, a healthy T'Challa, in his full Black Panther garb, has enhanced speed, strength, night vision, and healing ability. Additionally, he can summon short, cat-like Adamantium claws from his knuckles by balling his hands into fists. T'Chaka becomes outraged upon learning that S.H.I.E.L.D. (who had shut down Weapon X and freed T'Challa) now considers his son an asset of the U.S. and S.H.I.E.L.D. He subsequently sends M'Baku a letter, claiming that M'Baku, not T'Challa, is the titular "favorite son", and he implores M'Baku to return.

Fury has Captain America train and mentor the Panther, who reveals his damaged throat. Captain America, sympathizing for the Panther's plight, encourages Fury to place the Panther in the superhero team the Ultimates. This turns out to be a ruse in which Captain America impersonates the Panther, allowing T'Challa to escape and return home to Wakanda.[151]

Captain America later impersonates Black Panther during an Ultimates confrontation with the Juggernaut.[152]

After Ultimatum, Black Panther joins the New Ultimates.