Vaccination: The Dangerous Myth that will Kill, Part 5 of 5

in #science6 years ago

The previous 4 parts are located here:

  1. Vaccine: From Inoculation to Eradication, Part 1 of 5
  2. Vaccination: the Immune System of Phagocytes, Part 2 of 5
  3. Vaccination: to Kill that Which Isn't Living, Part 3 of 5
  4. Vaccination: A Case Study of Measles to Chickenpox, Part 4 of 5

Myth 1: Vaccines Cause Autism

The study is here[1] if you want to read it. I will just like to go through a few basic things first which is that there were only 12 subjects. Of the millions of people that et the MMR vaccine each year, only 12 were use to come to a conclusion. Most studies use as many participants as possible in order to drown out any statistical noise, this can mean in the hundreds to thousands if they can manage it yet this one came off with only 12 patients. Anyways if you want to read some posts that are directly attacking this study then go here[2] and here[3] . Warning, I cannot grantee the language in these posts, as they were not written by myself, I am linking them because I am not attacking the study, but the conclusion.

First off, there have been so many studies that actively dispute the claims of vaccines causing autism but first we need to dissociate the 3 main believed causes of this in order to debunk it. The causes were: MMR, Thimerosal, and Too Many Vaccines.

MMR

MMR (Measles, Mumps, Rubella) is a LAV (Live Attenuated Virus) vaccine that was linked to cause autism in a paper published on February 28th, 1998[4] .

Andrew Wakefield, a British gastroenterologist, and colleagues published a paper in The Lancet that described 8 children whose first symptoms of autism appeared within 1 month after receiving an MMR vaccine. All 8 of these children had gastrointestinal symptoms and signs and lymphoid nodular hyperplasia revealed on endoscopy. From these observations, Wakefield postulated that MMR vaccine caused intestinal inflammation that led to translocation of usually nonpermeable peptides to the bloodstream and, subsequently, to the brain, where they affected development.

From source [4]

Table 1 from Source [4], a list of studies (and where they were done) that were done within the years following the first publication, all of which refuted the conclusion of [1].

Due to the massive amounts of vaccinations happening, with the MMR vaccine, it was easy to have descriptive and observational studies conducted providing massive amounts of statistical data that denied the claims of the study conducted by Wakefield[1] and to add on to that, studies were not published that could confirm the findings of the original. There was even a study that looked at the number of people with autism before 1988 (when the MMR vaccine was introduced to the UK) and found that there was no change in the trend of people being diagnosed with autism from before the introduction[5]. There was even a second study that looked at similar data over a longer period of time and found no statistical difference between the rates of autism in those vaccinated against those that are not vaccinated. I could throw study after study onto this one showing there is no link between MMR and autism but in order to save time I will suggest just going to source 4 and reading those, much shorter

Thimerosal

Thimerosal is an organomercury antiseptic compound that was used in certain vaccines and in many tattoo inks[7]. Thimerosal is not contained in LAV vaccines[4] (meaning it isn't in the MMR vaccine) and has been phased out of routine childhood vaccines[8] due to public fears. Claims about the potential danger of thimerosal are unproven but tend to stem from, base on personal observations, the fact that it contains mercury. Now the fact that a compound contains something potentially toxic is a logical fallacy at best. For instance, table salt contains both sodium and chlorine (chlorine is pretty toxic in humans) yet due to how it bonds, it can be safely eaten. The reason for this is that the chemical properties of a substance change depending on the molecule, meaning some compounds containing mercury (including atomic mercury) will be toxic and some will not. Either way, the usage of thimerosal in childhood vaccines has stopped in the past 17 years. But now that we have showcased the logical fallacy of assumption, we can now move onto actually debunking claims of thimerosal being the culprit that causes autism. As many know, mercury poisoning and autism have 2 different sets of symptoms[4] which can rule out the degrading of the compound being the cause. A study done in 2004 looked at 140,887 children vaccinated with thimerosal containing vaccines and found no correlation between thimerosal and autism[9]. Another study looked at 2 groups, one with thimerosal vaccines and 1 without, between the years of 1990 and 1996 and determined that there wasn't any data to support a casual relationship between thimerosal and autism[10]. Again with thimerosal, same as MMR, there are more studies that conclude no link with autism then there are is time in the day to read them all. Research is still being conducted on the toxicity of thimerosal but in the quantities it is in in vaccines, it is unable to pose a threat.


Source here
Is not labeled for reuse but is also not copyrighted. I believe this edit originated on 4chan.

Too Many Vaccines

That old saying, too much of anything is never good is really ambiguous. How do yo define too much? Is one volume of something equivalent to another thing of similar volume when constituting what too much is? The problem with looking at pictures of this and saying that the amount of vaccines given looks scary is honestly because it is misleading. If we were to take the exact volumes of the vaccines given, you wouldn't even have a cup. I think a better reason to debunk this one though is that autism is not an immune-mediated affliction[4] but I will discuss that more below. The idea of how too many vaccines cases autism is the impression that the number of vaccines used can overwhelm the immune system but with vaccines getting better (from advances in the field) the current recommended vaccines actually require less of an immune response then in 1980[4] allowing for estimates of us being able to administer upwards of 1000 vaccines without compromising the immune system[4].

What is Autism?

So I should have probably put this first but I didn't because otherwise it would make it super obvious why vaccines are extremely unlikely to cause autism. Autism is an affliction caused by any group of multiple genetic mutations (hence autism spectral disorder) and depending on the mutation will actually change how to affects the person, so not all people with autism are more susceptible to emotions, stop spreading the lie. In our current model the mutations that cause something in the autistic spectrum do so by affecting development during the prenatal stages (before birth) meaning that doing something to them after they are born won't cause autism. The confusion comes because autism is usually determine between 18 and 36 months of age, before that it is way to difficult to tell[11]. Now what is interesting is that the rates of autism have been rising in the past 30 years but it is indeterminable on whether the rates are rising due to environmental conditions or because of newer techniques being used to diagnose the disorder[4][12][13]. What is apparent is that there is no determinable study that has been able to link autism with vaccines. Now on a side note, sing a logical fallacy here, what would you prefer to have a child with, autism or polio?

References for Myth 1

[1] www.sciencedirect.com/science/article/pii/S0140673697110960
[2] steemit.com/steemstem/@alexs1320/vaccine-and-autism-the-original-scientific-paper-let-s-read-it-together-and-see-why-it-s-a-bat-shit
[3] steemit.com/mathematics/@alexs1320/recognize-bad-math-learn-binomial-distribution-in-10-minutes
[4] academic.oup.com/cid/article/48/4/456/284219
[5] www.sciencedirect.com/science/article/pii/S0140673699012398
[6] ww.sciencedirect.com/science/article/pii/S0264410X01000974
[7[ www.hindawi.com/journals/jt/2012/373678/
[8] link.springer.com/article/10.2165%2F00002018-200528020-00001
[9] pediatrics.aappublications.org/content/112/5/1039
[10] jamanetwork.com/journals/jama/fullarticle/197365
[11] www.autismspeaks.org/what-autism
[12] www.scientificamerican.com/article/the-real-reasons-autism-rates-are-up-in-the-u-s/
[13] www.cdc.gov/ncbddd/autism/data.html


Myth 2: Vaccines are Harmless

This myth is in reference to some peoples arguments that vaccines are purely safe. Now, in most cases, the problems that arise from vaccines are cause by factors not controlled for such as a previously compromised immune system or an allergy. Now why I bring this up is that some people will make arguments stating that there is no way that a vaccine can cause a problem. The people that make this argument tend to be in support of science and vaccines but have little background in the subject matter in which this is a time to learn. Vaccines do have the potential to cause adverse effects, the rate of these effects is dependent on the vaccine itself as each vaccine has different rates. In the case of an adverse event we have implemented a system for reporting these effects so that the data can be analyzed and the vaccines studied further to make them safer but no vaccine will be 100% safe[1]. If you are allergic to something in the vaccine or have a compromised immune system, or a plethora of other conditions (doctors or pharmacists will ask) then you should not get a vaccine and in most cases will not. If you are unsure on whether you have an allergy, get an allergy test before the vaccine to determine.

Sources: Myth 2

[1] vaers.hhs.gov


Myth 3: Infant Mortality Rates

So this myth is quite interesting due to the fact there are actual scientific studies that have found a correlation here but the problem is how the study was done. First they took a list of all the countries based upon infant mortality rate (IMR), that had a lower and they graphed it when compared to number of vaccines given to infants and did a linear regression to prove correlation. This was similar to how I did the findings to determine correlation between gun laws and gun mortality rate[2] (by no means a good way to do things) but the difference was that I used ~100% of the data given in the scope, they used 33 data points of potentially 195. Now I could talk about my gun law correlation[2] post about how bad it was to do things that way and how I could do it better via larger population of data and to use random sampling but at least I didn't intentionally ignore data points that argued my point. Anyways the study/paper was done by Neil Z Miller and Gary S Goldman[1]. So the reason why this is considered a myth is due to faulty study and the fact that if you are getting published in a journal, you should be under a lot more scrutiny than someone blogging on steemit (no offense bloggers) but I guess I cannot completely ignore this... There is a potential that I am holding a bias here so I will instead discuss why a correlation between these doesn't necessarily mean anything. First of all, most of us have heard the phrase "Correlation does not imply causation" which means that just because 2 things are correlate, does not mean one of those things caused the other. Like for instance, if hours of TV watched correlated to amount of chips eaten, you wouldn't say eating chips made yo watch TV or that watching TV made you eat chips. This paper does nothing more than points out a correlation, without looking at any external factors or controlling for them, and states the following:

These findings demonstrate a counter-intuitive relationship: nations that require more vaccine doses tend to have higher infant mortality rates.
Which has been interpreted as a causality by many. There are other problems with this paper that it doesn't address that I won't get into here. There are better formulate arguments in a post by David Gorski[3]

References Myth 3

[1] www.ncbi.nlm.nih.gov/pmc/articles/PMC3170075/

[2]steemit.com/statistics/@kryzsec/analysis-for-correlation-between-the-number-of-gun-laws-by-state-and-gun-related-mortality-rate

[3] sciencebasedmedicine.org/vaccine-schedules-and-infant-mortality-a-false-relationship-promoted-by-the-anti-vaccine-movement/

Gorski Bio: sciencebasedmedicine.org/editorial-staff/david-h-gorski-md-phd-managing-editor/


The post is getting a little bit long and due to the stress on my schedule caused by exams I have been taking a break from looking at this. I will make a second part covering a few more of these myths (hopefully in better context) once this finishes. In the mean time I have planned a post about batteries that I have been working on but mostly I am working on the @steemstem-bot. Just to clarify something said, when I say I would hand over the bot after 13 weeks, that is just to power down anything that I put into the bot. So if it had gathered 300-400 SP from rewards (curation, author) then that would stay in it.


Fun Fact!

Peanuts may have "nut" in their name but they are actually legumes. Peanuts grow underound where as nuts (e.g. walnuts) grow on trees.
Source


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Image Source from @nitesh9

Do you enjoy reading or writing topics related to STEM (Science, Technology, Engineering, and Mathematics) then I would suggest checking out @steemstem! They do wonderful work curating the best STEM related posts on Steemit. For more information check out the SteemStem chat room on steemit.chat or check out their Guidlines and start writing.

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Hey, thanks for taking the time to address this highly contentious issue -- and relatively objectively at that. I am glad that you appreciate nuance within this subject (e.g. not stating that there are only positives, or dismissing others entirely, as adverse reactions can and may occur due to allergies or unforeseen immunological complications).

When I read the headline I thought to myself "Great, another conspiratorial headline to exploit fear for clicks Alex Jones style..." though, upon further inspection you actually did your homework. I appreciate that, and especially the citations that come from reputable, peer-reviewed sources. Glad to see others in the STEM fields on Steemit!

Remember, folks: Vaccines cause adults.
And if you like SMBC comics, remember that autism causes vaccines:

I tried to make the title click-baity enough to attempt to get some of the vaccine conspiracy people. I am glad that you read the article before commenting or creating a complete opinion (it happens sometimes) and would welcome you, if you write STEM related topics, to look into the steemstem group. (advertising over)

I did want to, at some point, go over specific vaccine case studies where they are not exactly perfect such as the anthrax vaccine trials and the on-going debate surrounding the varicella vaccine (chickenpox) but overall I just wanted to get information out there, on steemit, to try and build up a community of people that can call out the antivaccers.

Thank you for the info, I will check that group out! I am in the biotechnology field and it never ceases to amaze me what kind of dubious information you'll see online. Cheers for keeping it legitimate!

If you are interested in case studies on vaccines check out the immunization that was developed for Lyme disease; LYMErix™. This review (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870557/) offers a cautionary tale into public communication surrounding vaccine development and implementation.

Looking forward to seeing more!

I immediately loved that you made the title intentionally ambiguous, well done!

I am glad you enjoyed it

not gonna lie, the title sounds like an anti-vaxx article, and I almost face palmed. I'm glad their are other scientists on steemit

That was kind of the intent. Antivaccers like reading stuff that supports their ideas, I am trying to draw them in. I too am glad there are others that enjoy science on here.

Science is a religion, and this post is clearly in the wrong category. Only in America are people afraid of chicken pox lol

What? Science is a field of study that involved rigorous testing. Religion is a belief system that cannot be tested to determine if it is true or now.

My brother is legitimately allergic to some part of flu shot vaccines. I think my mom still went ahead and made him get them, has to be a hard call as a parent regardless.

See the allergy to vaccines is a medical reason to opt out, if there is a medical reason then I completely understand and agree with opting out but when the reason people opt out is because of fear of autism or some other myth spread around the antivac community it becomes quite worrisome... Where I live I have to fill out a form and be interviewed by the pharmacist before I can get the flu vaccine because they need to know for certain that it wont be detrimental.

Thank you so much for this series. I work in immunology, and have actually done some peer reviewed ""research"" on vaccines. I work in St. Louis, and sometimes my work takes me into the infectious disease wards in Children's Hospital.

It is one of the hardest things for a human being to witness to see the children in their isolation rooms. I was working with one child who was sick from complications from a disease that we have vaccinations for, and they cried and cried after being told that the therapy dog couldn't come in to see them for fear of spreading their illness to another immunocompromised child.

Every time we lose a child to vaccine preventable illnesses, we mourn. Sometimes I wish I could bring an anti-vax parent with me into the hospital to see what their arrogance and fear does to families.

I am super happy that people enjoy the series like you do. I wish I could know whether this series had the potential to do anything for swaying any parents that were teetering over to vaccination... though on steemit the anti-vac community is quite a bit larger. I have to be honest when I say that I am not completely certain how to respond to the entirety of your post other than saying that I truly hope that as many of those children survive as can. Thank you for sharing, and reading.

Thanks for your response.

I read somewhere that the most effective way to convince parents to vaccinate their children is to educate them on the reality of these illnesses, as vaccinations have been so effective as to let us forget about the devastation they caused families not so long ago. Unfortunately, this runs the risk of exploiting some of these kids, as pictures are the best wake to evoke a visceral reaction. I am planning on writing a post about it, once I find some sources besides my faulty memory.

The antivax community on here is actually really spurred my decision to get a steemit account. Any way I can contribute in the fight against science woo is welcome!

As for the kids, thanks for caring. They do good work here; I just wish parents wouldn't make their jobs any harder than they have to be.

Well if you plan on posting science related stuff, I truly recommend posting with the steemstem tag. It will provide you with a community of support and help you grow, as long as you post content to their degree of quality (cite sources, provide sources for photos, etc) and I truly hope to see yo around the community!

Hello, it's a pleasure! :-) I confess I'm curious about what motives have led you to undertake the writing of these 5 vaccines articles (as far as I've seen, you don't mention it)? Thanks in advance for your precisions!

Hi @ijatz,

My motives for these vaccines posts are that I enjoy studying the material and that I see a lot of misinformation being passed around.and I thought it would be good to add some more accurate information about vaccines on steemit. I don't know if that makes sense, sorry about the late reply though.

Hi again @kryzsec! Sure, it totally makes sense :-) Your publication quite amazed me, for being in this platform a leaf of freshness and thought amidst a forest of... well, vacuum and sensationalism :-/ I've been on Steemit for just some days, attracted by its mind empowering potential, and find myself overhelmed by an apparently generalized self-censorship and mainstrean conformity underlying many trendy contributions... As if their main justification was harvesting STEEM, rather than producing knowledge and a more enlightened community. Hope the STEM fields approach will help reverting that trends :-)

Important post! And I love your objectivity (myth no 2 etc.)

A rather off-topic question: what code do you use to do your superscripts?

Thanks fr the support!

And I use html for everything so for superscript I have <sup>superscript</sup>
Subscript looks like this or <sub>this</sub>

I am not certain how to do it in markdown (never bothered to learn it)
And nothing wrong with off-topic questions

I already knew the code for subscript, rather silly of me not to think I could use the same for superscript!

Thanks!

Sorry about the late reply. I also apologize if my reply seemed condescending, I just didn't know if you knew that and figured it would be better to be safe than sorry to include it. I am glad I cold help with the superscript at least! And your welcome

No, not condescending at all, no worries!

This is really awesome, TRULY well written! You seem to be very well researched on the subject, which comes through very clearly. This is why i go to the science part of steemit, to find new knowledge like this :) It's awesome to get new knowledge, and you definetely did this today :)

Btw, i wanted to tell you that i added you to my latest post about giving thanks :) As a new user, it means a lot when people give you a warm welcome. And as i have just handed in my final exam, i wanted to get back into steemit. And i had to start this by saying thank you. I hope you have a great christmas, and stay warm and cozy this December :)

Merry Christmas to you, I just finished reading your post! Thanks for the feedback on the post, I am glad you enjoyed it!

Sorry about the short response, I am still studying for my last 2 finals

I don't believe a word you are saying. You are a bloody scientist paid by pharmaceutical companies to spread your lies. Just look at our large anti-vaxxer community, how many of our people have personally suffered from vaccine-induced autism. :-P

God I wish I were paid by a pharmaceutical company. Post secondary cost a lot of money, and I think you completely missed the part where vaccines don't cause autism 😂😂😂😂

My son was damaged by the DPT vaccine. You wouldn't say they don't cause damage if it was your child that was damaged. In my sons case, his vaccine did NOT cause adulthood.

Read myth 2. Yes vaccines can cause adverse affects but they are rare and, in many cases, predictable. Sometimes in order to be predictable they would first require genetic screening (which is expensive) and a lot of testing. sing the information on the vaccine from the CDC website here you can look at the risk assessment to find out how rare it was (though I know this is no consolidation) for his exact condition. Another question comes with severity (as DTaP vaccines are not linked to any long term severe conditions) is whether it was coincidence that something happened after the vaccine or if it was actually cause by the vaccine (as so few people get moderate let alone serious)

So never did I say they are harmless, what I said was (in myth 2) that vaccines do have the potential to cause adverse effects (vaccine dependent) but everything in medicine has the potential to cause adverse affects. Considering a majority of people that receive the vaccine not only survive but survive with minimal no no adversities (even including minor ones) with exception of a sore arm shows that the vaccine has more of a potential to help then to harm. I am sorry about your son, but he isn't enough to classify them as dangerous, especially with the vague story that doesn't even bring in symptoms to confirm with other cases.

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