We have evidence of chewing coca in South America that began by at least 8000 cal BP (calibrated years before the present)

Yes, it is a good medicinal too. While on a trek in the jungle of South America. One of the tourists had a migraine. Let's just say they quickly remedied a headache. lol

Indigenous people made paintings of mushrooms on rock around 7000 BC while building temples to their deities and calling psilocybin containing mushroom “teonanácatl” or “Flesh of God”

Still in use today.

I enjoyed your research. :)