I do my best, but there are always things that slip through the cracks for sure. I have a lot of people ask me all the time what antivirus software they should buy and my usual reply is none. I don't know as though I would ever pay for AV software again. The fact is, the built in software with Windows does a fairly decent job and yeah we hear about hacks and ransomware and stuff like that, but when is the last time you really heard about a system crippling virus like Nimda or Sircam. It has literally been like twenty years. I think all of the things you mentioned here are things we should all be striving to achieve in our networks and systems though.
There will be indeed always things that will slip trough. The important thing is to minimize the risk and accept the rest-risk. And you are right, the big virus outbreaks are a long time ago..