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RE: Philosophy and The Binding of Isaac
Haven't played Binding of Issac, but I can relate to what you said because many rouge-likes has a bit of that relation to real-life, and I imagine one with religious references is going to be more obvious about it.
I enjoyed reading this :)
I do tend to be drawn to roguelikes in general, but I think BoI specifically is a treasure trove of philosophical retrospection.